Richard S Smith Selected Research

Glaucoma

1/2017	Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.
5/2014	A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].
3/2014	Determining immune components necessary for progression of pigment dispersing disease to glaucoma in DBA/2J mice.
6/2013	Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.
4/2012	Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.
6/2011	Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.
2/2011	Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma.
12/2007	Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model.
11/2006	Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
7/2005	Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.

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Richard S Smith Research Topics

Disease

12	Glaucoma 01/2017 - 03/2003
3	Retinal Degeneration 12/2008 - 03/2006
2	Optic Nerve Hypoplasia 10/2015 - 04/2007
2	Iris Diseases 03/2014 - 07/2006
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2013 - 01/2012
2	Open-Angle Glaucoma (Glaucoma, Open Angle) 10/2004 - 01/2002
1	Rubella (German Measles) 10/2020
1	Brain Diseases (Brain Disorder) 01/2020
1	Epilepsy (Aura) 01/2020
1	Pontocerebellar Hypoplasia 01/2018
1	Channelopathies 01/2018
1	Microcephaly 01/2018
1	Nail-Patella Syndrome (Syndrome, Nail-Patella) 05/2014
1	Microphthalmos 06/2011
1	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 06/2011
1	Male Infertility (Male Sterility) 01/2011
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 11/2009
1	Breast Neoplasms (Breast Cancer) 01/2009
1	Atrophy 12/2008
1	Optic Nerve Diseases (Optic Neuropathy) 12/2007
1	Oculocutaneous Albinism (Albinism, Yellow Mutant) 09/2007
1	Hypopigmentation (Hypomelanosis) 09/2007
1	Optic Nerve Injuries 07/2005
1	Neoplasms (Cancer) 05/2005
1	Neoplasm Metastasis (Metastasis) 05/2005
1	Asthma (Bronchial Asthma) 06/2004
1	Metrorrhagia (Spotting) 09/2003
1	Teratoma (Teratoid Tumor) 02/2002

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 03/2014 - 01/2002
3	Retinaldehyde (Retinal)IBA 02/2011 - 09/2003
2	Peptide Hydrolases (Proteases)FDA Link 10/2020 - 06/2011
2	Ion Channels (Ion Channel)IBA 01/2020 - 01/2018
2	Complement System Proteins (Complement)IBA 01/2017 - 06/2013
2	Collagen Type IV (Type IV Collagen)IBA 10/2015 - 04/2007
2	Mutant Proteins (Protein, Mutant)IBA 11/2006 - 10/2004
2	trabecular meshwork-induced glucocorticoid response proteinIBA 11/2006 - 10/2004
2	Monophenol Monooxygenase (Tyrosinase)IBA 07/2006 - 03/2003
1	4-trifluoromethylsalicylic acid (HTB)IBA 10/2020
1	Endosomal Sorting Complexes Required for TransportIBA 01/2018
1	Voltage-Gated Sodium ChannelsIBA 01/2018
1	RTKI cpdIBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 05/2014
1	Complement C5 (Complement 5)IBA 06/2013
1	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 06/2013
1	Endothelin-2IBA 04/2012
1	Phospholipid Transfer ProteinsIBA 01/2012
1	acceleratory factor from growth hormone (AcG)IBA 06/2011
1	Serine Proteases (Serine Protease)IBA 06/2011
1	prefoldinIBA 01/2011
1	GTP Phosphohydrolases (GTPases)IBA 11/2009
1	Estrogens (Estrogen)FDA Link 01/2009
1	Nonsense Codon (Nonsense Mutation)IBA 12/2008
1	RNA Splice SitesIBA 07/2008
1	WD repeat containing planar cell polarity effectorIBA 07/2008
1	Nitric Oxide Synthase (NO Synthase)IBA 12/2007
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 12/2007
1	cyclo(5- hydroxytryptophyl- 5- hydroxytryptophyl)IBA 09/2007
1	Melanins (Melanin)IBA 07/2006
1	Non-Receptor Type 6 Protein Tyrosine PhosphataseIBA 03/2006
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 07/2005
1	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 07/2005
1	AntigensIBA 05/2005
1	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2004
1	SteroidsIBA 10/2004
1	Protein SIBA 10/2004
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 06/2004
1	Cytochrome P-450 CYP1B1IBA 03/2003

Therapy/Procedure

2	Therapeutics 01/2017 - 06/2013
1	Radiotherapy 04/2012
1	Cautery 12/2007
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 03/2006
1	Euthanasia (Mercy Killing) 02/2002